Histological and mechanical properties of a new-type biopsy material

doi:10.3969/j.issn.2095-4344.2013.34.008

Abstract

Abstract:

BACKGROUND: The biopsy material induced by foreign body is autologous tissue, which, in theory, avoids the role of immune rejection and destruction faced by non-autologous implants. This biology advantage has no way to comparison by synthetic and de-cellular materials.

OBJECTIVE: To explore a biotube consisting of autologous cells and extracellular matrix and to evaluate its structure and mechanical features.

METHODS: The biotubes were prepared by embedding silicon rods as a mold intraperitoneally. Specimens were analyzed by mechanical tests, histological observation and superficial study.

RESULTS AND CONCLUSION: It was easy to excite the biotubes prepared by embedding silicon tube intraperitoneally. The biotube mainly included collagen-rich extracellular matrices and myofibroblasts appearing as elongated cells with circumferential or longitudinal orientations. At 1 month of embedding, the wall was 70- 250 μm in thickness and had burst strength of (1 100±187) mm Hg (1 mm Hg=0.133 kPa), with perfect sewability. The biotubes, which possess the ability for wide adjustments in their shapes, are composed of autologous cells and extracellular matrices, and are an ideal graft for tissue engineering because they avoid immunological rejection and have sufficient mechanical strength.

Key words: biomaterials, material biocompatibility, tissue-engineered vessels, autologous transplantation, biotube, autologous living tissue material, tensile strength, elongation at break, bursting strength, sweability, National 863 Program of China

CLC Number:

R318

Chen Xiao-song, Zhang Jian, Li Jian-xin. Histological and mechanical properties of a new-type biopsy material[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(34): 6110-6115.

Figures/Tables 6

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